Emilia Clarke, who made her debut in the Marvel Cinematic Universe with Secret Invasion, was also offered the role of Anastasia Steele from Fifty Shades of Grey, which later on was done by Dakota Johnson.

Source: https://www.koimoi.com/hollywood-news/when-emilia-clarke-rejected-fifty-shades-of-grey-for-having-too-much-of-ndity-making-place-for-dakota-johnson-said-the-entire-thing-is-about-sx/

Johnson, who plays Anastasia Steele, becomes romantically linked to Christian Grey (Jamie Dornan) and they act out their BDSM desires.

Source: https://www.independent.co.uk/arts-entertainment/films/news/movie-accidents-on-set-mistakes-b2318247.html